Target   IDP00259

Stage
in_pdb   (Predicted Ligands) PDB: 4FFE
Locus Tag
CPXV018  
NCBI Protein Lookup
gi: 30844336   accession: NC_003663  
Organism
Cowpox virus  
Common Name
Cowpox virus, complete genome  
Gene Name
CPXV229 CDS  
NCBI Annotation
soluble TNF receptor  
Comment
NK2D ligand: Blocks activation of innate immunity through NK-cell receptor  
Selection Phase
Phase 1: October 2007  
Date Approved
Dec 13, 2007  
Justification for Selection
These targets are similar to actual drug targets and will be used mostly for cocrystallisation with small molecules. The more information we have about the binding sites, the better are the chances to understand how the drug works and what modification can achieve.  
Priority
7  
Sequence Length
171  
(Subtargets)
 
pI
4.62  
Molecular Weight
20.3 kDa  
Sequence
MHLQYYAISL VSLVSLIDCH KLAFNFNLEI NGSDTHSTVD VYLDDSQIIT FDGKDIRPTI PFMIGDEIFL PFYKNVFSEF FSLFRRVPTS TPYEDLTYFY ECDYTDNKST FDQFYLYNGE EYTVKTQEAT NKNMWLTTSE FRLKKWFDGE DCIMHLRSLV RKMEDSKRNT G  
DNA Sequence
ATGCAT CTACAA TATTAT GCGATA TCTCTT GTATCT CTTGTA TCTCTT ATTGAC TGTCAC AAACTC GCATTC AACTTC AATCTA GAAATA AATGGC AGTGAT ACACAT TCTACA GTAGAT GTATAT CTTGAT GATTCT CAAATT ATAACG TTTGAT GGAAAA GATATC CGTCCA ACCATC CCGTTC ATGATA GGTGAT GAAATT TTCTTA CCGTTT TATAAA AATGTG TTTAGT GAGTTT TTCTCT CTGTTT AGAAGA GTTCCT ACAAGT ACTCCA TATGAA GACTTG ACATAT TTTTAT GAATGC GACTAT ACAGAC AATAAA TCTACA TTTGAT CAGTTT TATCTT TATAAT GGCGAA GAATAT ACTGTC AAAACA CAGGAG GCCACT AATAAA AATATG TGGCTA ACTACT TCCGAG TTTAGA CTAAAA AAATGG TTCGAT GGCGAA GATTGT ATAATG CATCTT AGATCG TTAGTT AGAAAA ATGGAG GACAGT AAACGA AACACT GGTTAG  
Inserted
Mar 14, 2008