Target   IDP00348

Stage
in_pdb   (Predicted Ligands) PDB: 3TFC, 3NVT
Locus Tag
lmo1600  
NCBI Protein Lookup
gi: 16803640   accession: NP_465125  
PATRIC Lookup
20312333  
Organism
Listeria monocytogenes EGD-e  
Common Name
bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase [Listeria monocytogenes EGD-e]  
Gene Name
aroA  
NCBI Annotation
catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate  
TIGR Main Role/Annotations
Amino acid biosynthesis  
TIGR Sub Role
Aromatic amino acid family  
Comment
Shikimate Pathway  
Selection Phase
Community Interest  
Date Approved
Apr 15, 2008  
Justification for Selection
Drug Target Function  
Priority
2  
Sequence Length
361  
(Subtargets)
 
pI
5.22  
Molecular Weight
39.7 kDa  
Sequence
MVNTNLEELR TQVDQLNIDL LELISKRANL VQEIGKIKGT QGSLRFDPLR EREMLNTILA ANEGPFEDST VQKLFKEIFK AGLELQEEDH SKALLVSRKN KKEDTIVTVK GLPIGNGEPV FVFGPCSVES YEQVAAVAES IKAKGLKLIR GGAFKPRTSP YDFQGLGLEG LKILKRVSDE YGLGVISEIV TPADIEVALD YVDVIQIGAR NMQNFELLKA AGRVDKPILL KRGLSATIEE FIGAAEYIMS QGNGKIILCE RGIRTYEKAT RNTLDISAVP ILKKETHLPV MVDVTHSTGR KDLLLPCAKA ALAIEADGVM AEVHPDPAVA LSDSAQQMDI PEFEEFWNAI LASNLVPHKI K  
DNA Sequence
ATGGTT AATACA AATTTA GAGGAA CTTAGA ACACAG GTGGAT CAATTA AATATT GATTTG CTAGAA TTAATT AGCAAA CGTGCT AATTTG GTACAA GAAATT GGCAAA ATTAAA GGAACT CAAGGT TCTCTT CGTTTT GATCCA TTACGT GAAAGA GAAATG CTTAAC ACGATT CTTGCA GCAAAT GAAGGA CCTTTT GAAGAT AGTACG GTTCAA AAATTA TTTAAA GAAATT TTTAAA GCGGGA TTAGAG CTTCAA GAAGAA GATCAC TCTAAA GCATTA CTCGTT TCTAGA AAAAAT AAAAAA GAAGAT ACGATA GTTACA GTAAAA GGCTTG CCAATT GGGAAT GGCGAA CCAGTA TTTGTT TTCGGT CCATGT TCAGTG GAATCT TATGAA CAAGTT GCTGCG GTTGCT GAATCC ATTAAA GCGAAA GGCTTA AAACTT ATTCGT GGTGGC GCATTT AAACCT CGTACT AGCCCA TATGAC TTCCAA GGATTA GGTTTA GAAGGA CTGAAA ATTTTA AAACGT GTATCT GATGAA TACGGT TTAGGT GTTATT AGTGAA ATCGTT ACGCCG GCTGAT ATTGAA GTTGCA CTTGAT TATGTA GATGTT ATTCAA ATTGGC GCAAGA AACATG CAAAAC TTCGAA TTACTA AAAGCA GCTGGC CGTGTG GACAAA CCAATC TTACTA AAACGT GGTTTA TCTGCT ACGATT GAAGAA TTCATT GGTGCT GCTGAA TATATC ATGTCA CAAGGA AATGGC AAAATC ATCTTA TGCGAA CGTGGT ATCCGC ACATAT GAAAAA GCGACA AGAAAT ACACTT GATATT TCTGCC GTTCCA ATTTTG AAAAAA GAAACC CATTTA CCAGTT ATGGTT GACGTG ACGCAT TCTACT GGCCGA AAAGAT TTATTA CTTCCA TGTGCG AAAGCT GCTCTA GCTATC GAAGCA GACGGT GTAATG GCTGAA GTTCAT CCAGAC CCTGCA GTTGCA TTATCG GATTCT GCACAA CAAATG GATATT CCTGAA TTTGAA GAATTC TGGAAT GCAATT TTAGCA AGTAAC TTAGTA CCACAT AAAATA AAGTAA  
Inserted
Apr 23, 2008