Target   IDP91634

Stage
in_pdb   (Predicted Ligands) PDB: 3TU3
Locus Tag
AAC16023  
NCBI Protein Lookup
gi: 2429143   accession: AAC16023  
Organism
Pseudomonas aeruginosa  
Common Name
ExoU [Pseudomonas aeruginosa]  
Gene Name
exoU  
Selection Phase
Community Requests  
Date Approved
May 06, 2011  
Justification for Selection
These targets are similar to actual drug targets and will be used mostly for cocrystallisation with small molecules. The more information we have about the binding sites, the better are the chances to understand how the drug works and what modification can achieve.  
Justification Codes
virulence/pathogenesis  
Priority
5  
Sequence Length
687  
(Subtargets)
 
Molecular Weight
73.9 kDa  
Sequence
MHIQSLGATA SSLNQEPVET PSQAAHKSAS LRQEPSGQGL GVALKSTPGI LSGKLPESVS DVRFSSPQGQ GESRTLTDSA GPRQITLRQF ENGVTELQLS RPPLTSLVLS GGGAKGAAYP GAMLALEEKG MLDGIRSMSG SSAGGITAAL LASGMSPAAF KTLSDKMDLI SLLDSSNKKL KLFQHISSEI GASLKKGLGN KIGGFSELLL NVLPRIDSRA EPLERLLRDE TRKAVLGQIA THPEVARQPT VAAIASRLQS GSGVTFGDLD RLSAYIPQIK TLNITGTAMF EGRPQLVVFN ASHTPDLEVA QAAHISGSFP GVFQKVSLSD QPYQAGVEWT EFQDGGVMIN VPVPEMIDKN FDSGPLRRND NLILEFEGEA GEVAPDRGTR GGALKGWVVG VPALQAREML QLEGLEELRE QTVVVPLKSE RGDFSGMLGG TLNFTMPDEI KAHLQERLQE RVGEHLEKRL QASERHTFAS LDEALLALDD SMLTSVAQQN PEITDGAVAF RQKARDAFTE LTVAIVSANG LAGRLKLDEA MRSALQRLDA LADTPERLAW LAAELNHADN VDHQQLLDAM RGQTVQSPVL AAALAEAQRR KVAVIAENIR KEVIFPSLYR PGQPDSNVAL LRRAEEQLRH ATSPAEINQA LNDIVDNYSA RGFLRFGKPL SSTTVEMAKA WRNKEFT  
DNA Sequence
ATGCAT ATCCAA TCGTTG GGGGCT ACTGCC TCCTCG CTGAAT CAGGAG CCTGTC GAAACC CCGTCG CAGGCA GCGCAT AAGTCC GCCAGC TTGCGT CAGGAA CCTTCA GGGCAA GGTCTC GGGGTT GCCCTA AAGAGC ACGCCG GGAATA CTTTCC GGGAAG TTGCCG GAAAGC GTTAGT GACGTG CGTTTC AGCAGT CCCCAA GGGCAA GGGGAG TCCCGT ACTCTG ACTGAC TCGGCA GGGCCG CGGCAG ATCACT CTGCGC CAGTTT GAGAAC GGAGTC ACCGAG CTACAG CTCAGT CGGCCA CCATTG ACCAGT CTGGTC CTAAGC GGCGGT GGTGCC AAAGGT GCGGCA TACCCG GGAGCA ATGCTG GCGCTA GAAGAG AAAGGC ATGCTC GATGGC ATCCGC AGCATG TCCGGT TCGTCC GCTGGC GGCATC ACCGCC GCCCTT TTGGCC TCAGGT ATGAGC CCGGCG GCGTTC AAGACC CTTTCC GACAAG ATGGAT CTTATT TCGCTG CTCGAT AGCTCG AACAAG AAGCTG AAGCTG TTCCAA CACATT AGCAGC GAGATC GGCGCA TCGCTG AAAAAG GGCTTG GGCAAC AAGATC GGCGGC TTCTCT GAGTTG CTGCTC AATGTA CTCCCA CGCATA GATTCG CGGGCT GAGCCC CTAGAA CGCCTA TTGCGC GACGAG ACACGC AAGGCC GTGCTC GGACAG ATCGCT ACGCAT CCAGAG GTTGCA CGCCAG CCGACC GTTGCC GCCATC GCCAGC AGATTG CAGTCC GGCTCC GGAGTC ACCTTT GGCGAT CTAGAT CGGTTG AGTGCT TACATT CCCCAG ATTAAG ACGCTG AACATC ACAGGT ACGGCC ATGTTC GAGGGG CGTCCG CAATTA GTGGTG TTCAAT GCCAGC CACACA CCGGAT CTGGAG GTCGCC CAGGCG GCACAT ATCTCC GGTTCC TTCCCA GGAGTG TTCCAG AAGGTC AGCTTG AGTGAT CAGCCG TACCAG GCCGGC GTAGAG TGGACA GAATTC CAGGAT GGCGGG GTGATG ATTAAC GTGCCG GTCCCT GAGATG ATCGAC AAGAAT TTTGAC AGCGGG CCACTG CGGCGC AACGAC AACCTG ATCCTT GAGTTC GAGGGC GAAGCT GGGGAG GTAGCG CCCGAC CGAGGT ACTAGG GGCGGC GCGCTC AAGGGC TGGGTC GTCGGG GTGCCT GCCCTG CAGGCG CGCGAA ATGCTG CAGCTC GAGGGC CTGGAG GAATTG CGCGAG CAAACC GTTGTG GTGCCG TTGAAG AGCGAG CGCGGT GATTTC AGTGGC ATGCTC GGTGGC ACCTTG AACTTC ACCATG CCGGAC GAGATC AAGGCG CATCTT CAGGAG CGCCTC CAGGAG CGAGTC GGTGAA CATCTG GAGAAA CGTCTT CAGGCT TCAGAG CGTCAT ACCTTC GCTTCT CTCGAC GAGGCG CTGCTG GCACTT GATGAC AGTATG CTCACC AGTGTT GCTCAA CAGAAC CCGGAG ATCACA GACGGG GCGGTG GCTTTT CGCCAG AAGGCG CGGGAT GCGTTC ACCGAG CTGACT GTCGCT ATCGTT AGCGCC AATGGC TTGGCG GGTAGG CTCAAG TTGGAC GAGGCT ATGCGC TCCGCT CTTCAG CGACTC GATGCG CTGGCA GATACT CCGGAA CGCCTA GCATGG TTGGCA GCTGAG TTGAAC CATGCT GATAAC GTTGAT CATCAG CAGTTA CTCGAT GCCATG CGCGGG CAGACG GTGCAG TCGCCG GTGCTC GCCGCT GCGTTA GCAGAG GCGCAG CGCCGC AAAGTG GCGGTT ATTGCC GAGAAC ATTCGT AAGGAA GTTATC TTCCCC TCTCTG TATCGC CCTGGC CAGCCG GATTCC AACGTA GCTCTG TTACGT CGGGCG GAGGAG CAGCTA CGGCAT GCCACC AGTCCG GCGGAA ATCAAT CAAGCG CTGAAC GATATC GTCGAC AACTAC TCGGCA CGAGGC TTCCTG CGTTTC GGCAAA CCCTTG AGTTCG ACTACC GTTGAG ATGGCT AAGGCT TGGCGG AATAAG GAGTTC ACATGA  
Inserted
May 06, 2011