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Target   IDP91458

Stage
in_pdb   : 4E6Y
Locus Tag/Selection DB Lookup
VV1_0162  
NCBI Protein Lookup
gi: 27363645   accession: NC_004459  
PATRIC Lookup
20157127  
Organism
Vibrio vulnificus CMCP6  
Common Name
type II citrate synthase [Vibrio vulnificus CMCP6]  
Gene Name
gltA  
Selection Phase
Community Requests  
Date Approved
Mar 09, 2011  
Justification for Selection
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essential genes for Vibrio vulnificus. 2. TTSS (type III secretion system) and toxin for Vibrio vulnificus and TTSS (type III secretion system) for Vibrio parahaemolyticus. Vibrio parahaemolyticus: - the virulence proteins in this Vibrio are related to type III secretion systems (effector proteins) It would be interesting to target: - type III secretion systems (effector proteins) - same targets in Vibrio cholerae (if we have not targeted them yet) Vibrio vulnificus: - this Vibrio does not have type III secretion systems It would be interesting to target: - toxin related to the RtxA from Vibrio cholerae - essential proteins (potential drug targets) - we could also target the essential proteins that we have targeted in Vibrio cholerae but that have failed so far - we could look at the list of essential proteins targeted in Vibrio cholerae, remove the targets that have been successful, and of the unsuccessful targets pick the homologs in Vibrio vulnificus and parahaemolyticus  
Justification Codes
essential/virulence/pathogenesis  
Priority
4  
Sequence Length
429  
(Subtargets)
 
Molecular Weight
48.3 kDa  
Sequence
MADKKATLHV EGKAPIELPI MEGSLGTPVI DVRKLGANGY FTFDPGFLAT ASCESQITYI DGGKGILLHR GYPIDQLANN ADYLEVCYIL LYGEAPTREQ YEKFKTTVTR HTMVHEQIAS FFHGFRRDAH PMAVMCGVVG ALAAFYHDSL DINNDLHREI TAYRLLSKMP TLAAMCYKYS TGQPFIYPRN DLSYAENFLH MMFATPCEEY EVNPVVARAM DKIFTLHADH EQNASTSTVR LAGSSGANPF ACIAAGIASL WGPAHGGANE ACLKMLEEIG SVDNIPEYVD RAKDKDDPFR LMGFGHRVYK NYDPRATVMR ETCHEVLKEL NIQDPLLDVA MELERIALSD EYFVSKKLYP NVDFYSGIIL KAIGIPVSMF TVIFAISRTI GWIAHWNEMH SDPLNRIGRP RQLYTGEVQR DFQPMHERE  
DNA Sequence
atggcg gataag aaagcg accctt catgtt gaaggt aaagcg ccgatc gaattg ccaatt atggaa ggttct ttggga acgcct gtaatt gatgtt cgtaag ctagga gcgaac ggctac ttcact ttcgac ccgggt tttctt gccact gcatct tgtgaa tcgcaa ataaca tacatc gacggc ggaaaa ggcatc ctgctt caccgt ggatac cctatt gatcag cttgca aacaac gctgat taccta gaggtt tgttat attcta ctttac ggtgaa gcccct actcgt gagcaa tacgag aaattc aaaaca actgtt actcgc cacact atggtg cacgaa caaatt gccagc ttcttc catggc ttccgt cgtgat gcacac cctatg gcagta atgtgt ggtgtt gttggc gcactt gctgcg ttctac cacgat tctcta gacatc aataat gacctg caccgt gagatc acagcg tatcgt ctgttg tctaag atgccg actttg gctgcg atgtgt tacaag tactct acaggc cagccg ttcatc taccct cgcaat gatttg agctac gcagaa aacttc ctacac atgatg tttgct acacca tgtgaa gaatat gaagta aaccct gtcgtt gcacgt gcgatg gacaaa atcttc actctg cacgca gaccac gaacaa aatgcg tcaacg tcaacg gtacgt ttggcg ggttct tctggt gcaaac ccgttt gcttgt attgcg gcaggt attgca tcgctt tggggt ccagct catggc ggcgca aatgaa gcgtgt ttgaag atgttg gaagag attggt tcagtc gacaac attcct gagtac gtggat cgagcg aaagac aaagat gaccca ttccgt ttgatg ggcttt ggtcac cgtgtt tacaag aactac gatcca cgcgca accgtc atgcgt gaaacc tgtcat gaagtg cttaaa gagctc aacatt caagat ccactg cttgat gttgca atggaa cttgag cgtatt gctctt tcagac gagtac tttgta tcgaag aaactg tacccg aacgtt gatttc tactca ggcatc attctg aaagcg attggc attcca gtttca atgttt accgtt atcttc gcaatt tcacgc accatc ggttgg attgca cactgg aacgaa atgcac agtgac ccactg aaccgt atcggt cgccct cgccag ttgtac acaggg gaagtc caacgc gatttc caacct atgcac gaacgc gagtaa  
Inserted
Mar 09, 2011