Target   IDP91458

Stage

in_pdb   : 4E6Y

Locus Tag/Selection DB Lookup

VV1_0162  

NCBI Protein Lookup

gi: 27363645   accession: NC_004459  

Organism

Vibrio vulnificus CMCP6  

Common Name

type II citrate synthase [Vibrio vulnificus CMCP6]  

Gene Name

gltA  

NCBI Gene Lookup

 

NCBI Annotation

 

TIGR Main Role/Annotations

 

TIGR Sub Role

 

Comment

0  

Selection Phase

Community Requests  

Date Approved

Mar 09, 2011  

Justification for Selection

Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essential genes for Vibrio vulnificus. 2. TTSS (type III secretion system) and toxin for Vibrio vulnificus and TTSS (type III secretion system) for Vibrio parahaemolyticus. Vibrio parahaemolyticus: - the virulence proteins in this Vibrio are related to type III secretion systems (effector proteins) It would be interesting to target: - type III secretion systems (effector proteins) - same targets in Vibrio cholerae (if we have not targeted them yet) Vibrio vulnificus: - this Vibrio does not have type III secretion systems It would be interesting to target: - toxin related to the RtxA from Vibrio cholerae - essential proteins (potential drug targets) - we could also target the essential proteins that we have targeted in Vibrio cholerae but that have failed so far - we could look at the list of essential proteins targeted in Vibrio cholerae, remove the targets that have been successful, and of the unsuccessful targets pick the homologs in Vibrio vulnificus and parahaemolyticus  

Justification Codes

essential/virulence/pathogenesis  

Priority

8  

Sequence Length

429  

(Subtargets)

 

pI

0.00  

Molecular Weight

48.3 kDa  

Sequence

(Check Homologs)

MADKKATLHV EGKAPIELPI MEGSLGTPVI DVRKLGANGY FTFDPGFLAT ASCESQITYI DGGKGILLHR GYPIDQLANN ADYLEVCYIL LYGEAPTREQ YEKFKTTVTR HTMVHEQIAS FFHGFRRDAH PMAVMCGVVG ALAAFYHDSL DINNDLHREI TAYRLLSKMP TLAAMCYKYS TGQPFIYPRN DLSYAENFLH MMFATPCEEY EVNPVVARAM DKIFTLHADH EQNASTSTVR LAGSSGANPF ACIAAGIASL WGPAHGGANE ACLKMLEEIG SVDNIPEYVD RAKDKDDPFR LMGFGHRVYK NYDPRATVMR ETCHEVLKEL NIQDPLLDVA MELERIALSD EYFVSKKLYP NVDFYSGIIL KAIGIPVSMF TVIFAISRTI GWIAHWNEMH SDPLNRIGRP RQLYTGEVQR DFQPMHERE  

DNA Sequence

atggcg gataag aaagcg accctt catgtt gaaggt aaagcg ccgatc gaattg ccaatt atggaa ggttct ttggga acgcct gtaatt gatgtt cgtaag ctagga gcgaac ggctac ttcact ttcgac ccgggt tttctt gccact gcatct tgtgaa tcgcaa ataaca tacatc gacggc ggaaaa ggcatc ctgctt caccgt ggatac cctatt gatcag cttgca aacaac gctgat taccta gaggtt tgttat attcta ctttac ggtgaa gcccct actcgt gagcaa tacgag aaattc aaaaca actgtt actcgc cacact atggtg cacgaa caaatt gccagc ttcttc catggc ttccgt cgtgat gcacac cctatg gcagta atgtgt ggtgtt gttggc gcactt gctgcg ttctac cacgat tctcta gacatc aataat gacctg caccgt gagatc acagcg tatcgt ctgttg tctaag atgccg actttg gctgcg atgtgt tacaag tactct acaggc cagccg ttcatc taccct cgcaat gatttg agctac gcagaa aacttc ctacac atgatg tttgct acacca tgtgaa gaatat gaagta aaccct gtcgtt gcacgt gcgatg gacaaa atcttc actctg cacgca gaccac gaacaa aatgcg tcaacg tcaacg gtacgt ttggcg ggttct tctggt gcaaac ccgttt gcttgt attgcg gcaggt attgca tcgctt tggggt ccagct catggc ggcgca aatgaa gcgtgt ttgaag atgttg gaagag attggt tcagtc gacaac attcct gagtac gtggat cgagcg aaagac aaagat gaccca ttccgt ttgatg ggcttt ggtcac cgtgtt tacaag aactac gatcca cgcgca accgtc atgcgt gaaacc tgtcat gaagtg cttaaa gagctc aacatt caagat ccactg cttgat gttgca atggaa cttgag cgtatt gctctt tcagac gagtac tttgta tcgaag aaactg tacccg aacgtt gatttc tactca ggcatc attctg aaagcg attggc attcca gtttca atgttt accgtt atcttc gcaatt tcacgc accatc ggttgg attgca cactgg aacgaa atgcac agtgac ccactg aaccgt atcggt cgccct cgccag ttgtac acaggg gaagtc caacgc gatttc caacct atgcac gaacgc gagtaa  

Inserted

Mar 09, 2011