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Target   IDP00102

Stage
crystallized  
Locus Tag/Selection DB Lookup
NT01SF2944  
NCBI Protein Lookup
gi: 30042031   accession: AAP17757  
PATRIC Lookup
18706749  
Organism
Shigella flexneri 2a str. 2457T  
Common Name
putative positive transcription regulator (sensor EvgS)  
Gene Name
evgA  
NCBI Annotation
putative regulator; Not classified; residues 1 to 204 of 204 are 86.27 pct identical to residues 1 to 204 of 204 from Escherichia coli K-12 : B2369  
TIGR Main Role/Annotations
Cell envelope  
TIGR Sub Role
Surface structures  
Selection Phase
Phase 1: October 2007  
Date Approved
Dec 13, 2007  
Justification for Selection
These targets are similar to actual drug targets and will be used mostly for cocrystallisation with small molecules. The more information we have about the binding sites, the better are the chances to understand how the drug works and what modification can achieve.  
Priority
7  
Sequence Length
204  
(Subtargets)
 
pI
7.43  
Molecular Weight
22.7 kDa  
Sequence
MNAIIIDDHP LAIAAIRNLL IKNDIEILAE LTEGGSAVQR VETLKPDIVI IDVDIPGVNG IQVLETLRKR QYSGIIIIVS AKNDHFYGKH CADAGANGFV SKKEGMNNII AAIEAAKNGY CYFPFSLNRF VGSLTSDQQK LDSLSKQEIS VMRYILDGKD NNDIAEKMFI SNKTVSTYKS RLMEKLECKS LMDLYTFAQR NKIG  
DNA Sequence
ATGAAC GCAATA ATTATT GATGAC CATCCT CTTGCT ATCGCA GCAATT CGTAAT TTATTG ATCAAA AACGAT ATTGAA ATCTTA GCGGAG TTAACT GAAGGC GGAAGC GCCGTT CAGCGG GTGGAA ACACTT AAGCCT GATATC GTCATC ATTGAT GTCGAT ATCCCC GGAGTT AACGGT ATCCAG GTGTTA GAAACG CTGAGG AAGCGC CAATAT AGCGGA ATTATT ATTATC GTCTCC GCTAAA AATGAC CATTTT TACGGG AAACAT TGTGCT GATGCT GGCGCT AATGGT TTCGTG AGTAAA AAAGAA GGCATG AACAAT ATCATT GCGGCT ATTGAA GCTGCA AAAAAT GGCTAC TGCTAT TTCCCC TTCTCT CTCAAC CGGTTT GTTGGA AGTTTA ACGTCC GACCAG CAAAAA CTCGAC TCCTTA TCGAAA CAAGAA ATTAGT GTCATG CGGTAT ATTCTT GATGGC AAGGAT AATAAT GACATT GCGGAA AAAATG TTCATC AGCAAC AAAACT GTCAGC ACGTAT AAAAGT CGCCTG ATGGAA AAATTA GAATGT AAATCA CTGATG GATCTT TACACA TTCGCG CAACGT AACAAA ATCGGC TAA  
Inserted
Dec 19, 2007