Target   IDP91564

Stage

in_crystallization_trials  

Locus Tag/Selection DB Lookup

BAB34271  

NCBI Protein Lookup

gi: 13360307   accession: BA000007  

Organism

Escherichia coli O157:H7 str. Sakai  

Common Name

hypothetical protein [Escherichia coli O157:H7 str. Sakai]  

Gene Name

ECs0848  

NCBI Gene Lookup

 

NCBI Annotation

 

TIGR Main Role/Annotations

 

TIGR Sub Role

 

Comment

0  

Selection Phase

Community Requests  

Date Approved

Apr 12, 2011  

Justification for Selection

These targets are similar to actual drug targets and will be used mostly for cocrystallisation with small molecules. The more information we have about the binding sites, the better are the chances to understand how the drug works and what modification can achieve.  

Justification Codes

virulence/pathogenesis  

Priority

8  

Sequence Length

293  

(Subtargets)

 

pI

0.00  

Molecular Weight

32.4 kDa  

Sequence

(Check Homologs)

MLSPYSVNLG CSWNSLTRNL TSPDNRVLSS VRDAAVHSDN GAQVKVGNRT YRVVATDNKF CVTRESHSGC FTNLLHRLGW PKGEISRKIE VMLNASPVSA AMERGIVHSN RPDLPPVDYA PPELPSVDYN RLSVPGNVIG KGGNAVVYED AEDATKVLKM FTTSQSNEEV TSEVRCFNQY YGAGSAEKIY GNNGDIIGIR MDKINGESLL NISSLPAQAE HAIYDMFDRL EQKGILFVDT TETNVLYDRA KNEFNPIDIS SYNVSDRSWS ESQIMQSYHG GKQDLISVVL SKI  

DNA Sequence

ATGTTA TCGCCA TATTCT GTAAAT TTGGGA TGTTCA TGGAAT TCTTTA ACCAGA AACCTG ACTTCG CCTGAT AATCGT GTTTTA TCCTCT GTAAGG GATGCT GCCGTT CATTCT GATAAT GGGGCG CAAGTA AAGGTT GGCAAC AGAACA TATCGT GTTGTT GCCACC GATAAT AAGTTT TGCGTT ACAAGA GAAAGT CATAGT GGTTGT TTTACT AATCTG TTGCAC AGGCTG GGATGG CCTAAG GGGGAG ATTAGC AGGAAA ATTGAG GTCATG CTGAAT GCATCA CCAGTG AGCGCT GCTATG GAAAGA GGCATT GTTCAT TCGAAC AGACCT GATTTA CCTCCT GTTGAT TATGCA CCGCCA GAGTTA CCGAGT GTGGAC TATAAC AGGTTG TCAGTA CCTGGT AATGTT ATTGGC AAAGGG GGGAAC GCTGTA GTATAT GAAGAT GCTGAG GATGCA ACAAAA GTCCTG AAGATG TTTACT ACATCT CAAAGC AATGAA GAGGTG ACAAGC GAAGTT CGTTGC TTCAAC CAATAT TATGGT GCCGGG AGTGCA GAAAAA ATATAT GGCAAT AATGGT GATATT ATTGGT ATTAGA ATGGAT AAAATA AATGGA GAATCG CTTTTA AATATT TCGTCC TTGCCA GCACAG GCTGAG CATGCT ATTTAC GATATG TTTGAT AGACTG GAGCAA AAAGGA ATTCTT TTTGTC GATACA ACAGAG ACAAAT GTCTTA TATGAC CGCGCG AAGAAT GAGTTT AATCCA ATAGAT ATATCA TCTTAT AATGTT TCCGAC CGTTCA TGGAGT GAAAGT CAAATA ATGCAA TCTTAT CATGGC GGAAAG CAAGAT CTTATT AGTGTG GTATTA AGTAAA ATTTAG  

Inserted

Apr 12, 2011