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Target   IDP91564

Stage
in_crystallization_trials  
Locus Tag/Selection DB Lookup
BAB34271  
NCBI Protein Lookup
gi: 13360307   accession: BA000007  
PATRIC Lookup
18374323  
Organism
Escherichia coli O157:H7 str. Sakai  
Common Name
hypothetical protein [Escherichia coli O157:H7 str. Sakai]  
Gene Name
ECs0848  
Selection Phase
Community Requests  
Date Approved
Apr 12, 2011  
Justification for Selection
These targets are similar to actual drug targets and will be used mostly for cocrystallisation with small molecules. The more information we have about the binding sites, the better are the chances to understand how the drug works and what modification can achieve.  
Justification Codes
virulence/pathogenesis  
Priority
4  
Sequence Length
293  
(Subtargets)
 
Molecular Weight
32.4 kDa  
Sequence
MLSPYSVNLG CSWNSLTRNL TSPDNRVLSS VRDAAVHSDN GAQVKVGNRT YRVVATDNKF CVTRESHSGC FTNLLHRLGW PKGEISRKIE VMLNASPVSA AMERGIVHSN RPDLPPVDYA PPELPSVDYN RLSVPGNVIG KGGNAVVYED AEDATKVLKM FTTSQSNEEV TSEVRCFNQY YGAGSAEKIY GNNGDIIGIR MDKINGESLL NISSLPAQAE HAIYDMFDRL EQKGILFVDT TETNVLYDRA KNEFNPIDIS SYNVSDRSWS ESQIMQSYHG GKQDLISVVL SKI  
DNA Sequence
ATGTTA TCGCCA TATTCT GTAAAT TTGGGA TGTTCA TGGAAT TCTTTA ACCAGA AACCTG ACTTCG CCTGAT AATCGT GTTTTA TCCTCT GTAAGG GATGCT GCCGTT CATTCT GATAAT GGGGCG CAAGTA AAGGTT GGCAAC AGAACA TATCGT GTTGTT GCCACC GATAAT AAGTTT TGCGTT ACAAGA GAAAGT CATAGT GGTTGT TTTACT AATCTG TTGCAC AGGCTG GGATGG CCTAAG GGGGAG ATTAGC AGGAAA ATTGAG GTCATG CTGAAT GCATCA CCAGTG AGCGCT GCTATG GAAAGA GGCATT GTTCAT TCGAAC AGACCT GATTTA CCTCCT GTTGAT TATGCA CCGCCA GAGTTA CCGAGT GTGGAC TATAAC AGGTTG TCAGTA CCTGGT AATGTT ATTGGC AAAGGG GGGAAC GCTGTA GTATAT GAAGAT GCTGAG GATGCA ACAAAA GTCCTG AAGATG TTTACT ACATCT CAAAGC AATGAA GAGGTG ACAAGC GAAGTT CGTTGC TTCAAC CAATAT TATGGT GCCGGG AGTGCA GAAAAA ATATAT GGCAAT AATGGT GATATT ATTGGT ATTAGA ATGGAT AAAATA AATGGA GAATCG CTTTTA AATATT TCGTCC TTGCCA GCACAG GCTGAG CATGCT ATTTAC GATATG TTTGAT AGACTG GAGCAA AAAGGA ATTCTT TTTGTC GATACA ACAGAG ACAAAT GTCTTA TATGAC CGCGCG AAGAAT GAGTTT AATCCA ATAGAT ATATCA TCTTAT AATGTT TCCGAC CGTTCA TGGAGT GAAAGT CAAATA ATGCAA TCTTAT CATGGC GGAAAG CAAGAT CTTATT AGTGTG GTATTA AGTAAA ATTTAG  
Inserted
Apr 12, 2011