Center for Structural Genomics of Infectious Diseases

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Structure of IDP91095

CSGID target: IDP91095
PDB Id: 3POL (NCBI MMDB)
Authors: G.Minasov,A.Halavaty,L.Shuvalova,I.Dubrovska,J.Winsor,L.Papazisi,W.F.Anderson,Center For Structural Genomics Of Infectious Diseases (Csgid)
Responsible person: George Minasov
Responsible lab: Northwestern University
Deposition Date: Nov 22, 2010
Release Date: Dec 08, 2010

Description: Lipopolysaccharide 3-Deoxy-D-manno-octulosonic Acid (KDO) is an essential component of the lipopolysaccharide (LPS) layer. Cells defective in KDO biosynthesis have a compromised LPS and are usually less pathogenic and more susceptible to antibiotics. The enzyme 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase; CKS) catalyzes the activation of 3-deoxy-D-manno-octulosonate (or 2-keto-3-deoxy-manno-octonic acid; KDO) by forming CMP-KDO. The enzymes belong to cytidylyltransferase protein family being a part of GT-A clan that contains diverse glycosyltransferases that possess a Rossmann like fold. KDO is an essential component of lipopolysaccharides (LPS) in Gram-negative bacteria. Incorporation of KDO into LPS requires its activation by 3-deoxy-manno-octulosonate CKS. CKS is an attractive target for the development of antibacterial agents.
Functional assignment

Ligand code	Name	Ligand type