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Structure of IDP91143

2.2 Angstrom Resolution Crystal Structure of Superantigen-like Protein from Staphylococcus aureus subsp. aureus NCTC 8325.

Edit deposit information
CSGID target
IDP91143 
PDB Id
3R2T (NCBI MMDB
Authors
G.Minasov,A.Halavaty,L.Shuvalova,I.Dubrovska,J.Winsor,O.Kiryukhina,F.Falugi,M.Bottomley,F.Bagnoli,G.Grandi,W.F.Anderson,Center For Structural Genomics Of Infectious Diseases (Csgid) 
Responsible person
George Minasov 
Responsible lab
Northwestern University 
Deposition Date
Mar 14, 2011 
Release Date
Mar 23, 2011 

Annotation

Description
Staphylococcus aureus is a ubiquitous pathogen causing infections in humans and domestic animals. It is often associated with bovine mastitis. Among secreted virulence factors, the leukotoxins constitute a family of toxins, which induce Ca2+ influx and pore formation that allows ethidium entry. SAOUHSC_00393 is a superantigen-like protein, type I toxin, which binds to a receptor on the cell surface and stimulates intracellular signaling pathways. These toxins are excreted by microoragism and cause damage to the host by destroying cells or disrupting normal cellular metabolism. Most exotoxins can be destroyed by heating and they are susceptible to antibodies produced by the immune system, but many exotoxins are so toxic that they may be fatal to the host before the immune system has a chance to mount defenses against it. 
Functional assignment
superantigen-like protein 

Ligands

Ligand code Name Ligand type
175 3,5-dihydro-5-methylidene-4h-imidazol-4-on

Structure information

Unit cell parameters

Space Group
P 21 21 21  
Unit Cell

a=51.70Å, b=72.31Å, c=123.96Å
α=90.00, β=90.00, γ=90.00 
Solvent content
 
Matthews coefficient
 

Refinement

Data for the highest resolution shell is in parentheses.
Resolution range
29.63-2.21Å (2.26-2.21Å)  
Rall(%)
20.8 
Rwork(%)
20.5 (24.9) 
Rfree(%)
25.2 (27.8) 
Num. observed reflections
23975 (1666) 
Num. Rfree reflections
1222 (81) 
Completeness(%)
99.6 (95.0) 

Model parameters

Num Atoms
3363  
Num Waters
144  
Num Hetatoms
156  
Model mean isotropic B factor
52.600Å2  
RMSD bond length
0.012Å  
RMSD bond angle
1.569°  
Filename uploaded
rcsb064417.pdb (uploaded on Mar 24, 2011 12:14 PM)  
Inserted
Mar 24, 2011