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Structure of IDP04345

Crystal structure of Uridine Phosphorylase from Vibrio cholerae O1 biovar El Tor

Edit deposit information
CSGID target
IDP04345 
PDB Id
3O6V (NCBI MMDB
Authors
N.Maltseva,Y.Kim,J.Hasseman,W.F.Anderson,A.Joachimiak,Center For Structural Genomics Of Infectious Diseases (Csgid) 
Responsible person
Natalia Maltseva 
Responsible lab
Argonne National Laboratory 
Deposition Date
Jul 29, 2010 
Release Date
Oct 13, 2010 

Annotation

Description
Uridine phosphorylase is an enzyme which participates in pyrimidine metabolism and belongs to the family of glycosyltransferases. It catalyzes the reversible phosphorolysis of uridine with the formation of alpha-D-ribose-1-phosphate and uracil. Crystal structure of uridine phosphorylase from Vibrio cholerae O1 biovar El Tor was solved at 1.7 A resolution.  
Functional assignment
drug target; conserved gene; putative drug target function 

Ligands

Ligand code Name Ligand type
GOL
FMT

Structure information

Unit cell parameters

Space Group
H 3  
Unit Cell

a=93.07Å, b=93.07Å, c=155.57Å
α=90.00, β=90.00, γ=120.00 
Solvent content
46.95  
Matthews coefficient
2.32  

Refinement

Data for the highest resolution shell is in parentheses.
Resolution range
35.78-1.70Å (1.76-1.70Å)  
Rall(%)
14.9 
Rwork(%)
14.8 (23.3) 
Rfree(%)
17.8 (26.1) 
Num. observed reflections
58058 (5410) 
Num. Rfree reflections
2949 (278) 
Completeness(%)
99.1 (97.0) 

Model parameters

Num Atoms
4575  
Num Waters
600  
Num Hetatoms
15  
Model mean isotropic B factor
23.580Å2  
RMSD bond length
0.008Å  
RMSD bond angle
1.155°  
RMSD dihedral angle
12.959°
 
Filename uploaded
dep.pdb (uploaded on Jul 29, 2010 12:24 PM)  
Inserted
Jul 29, 2010