Center for Structural Genomics of Infectious Diseases

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Structure of IDP00067

CSGID target: IDP00067
PDB Id: 3PFI (NCBI MMDB)
Authors: 'A.S.Halavaty,Z.Wawrzak,T.Skarina,O.Onopriyenko,A.Edwards,A.Savchenko,W.F.Anderson,Center For Structural Genomics Of Infectious Diseases (Csgid)'
Responsible person: Andrei Halavaty
Responsible lab: Northwestern University
Deposition Date: Oct 28, 2010
Release Date: Nov 10, 2010

Description: The structure of the putative Se-Met holliday junction DNA helicase (ruvB) from Campylobacter jejuni subsp. jejuni NCTC 11168 in complex with ADP was solved by SAD. There are two copies of the protein in the H32 space group’s asymmetric unit, which form a dimer with the buried surface area of ~2700 A2. Single chain of the putative helicase consists of three distinct domains and binds one copy of ADP molecule. All three domains are involved in dimerization. Examining the crystal packing, it can be seen that protein forms a hexamer with the buried surface area of 16460 A2 and having ~22 A wide channel in the middle of the oligomer.
Functional assignment: HYDROLASE

Ligand code	Name	Ligand type
MSE		modified residue
175	3,5-dihydro-5-methylidene-4h-imidazol-4-on	biological