To see full content of that page you need the activeISee plugin.
Get the latest version from here.

Structure of IDP00770

Crystal Structure of Superantigen-like Protein, Exotoxin SACOL0473 from Staphylococcus aureus subsp. aureus COL

Edit deposit information
CSGID target
IDP00770 
PDB Id
3R2I (NCBI MMDB
Authors
E.V.Filippova,G.Minasov,A.Halavaty,L.Shuvalova,J.Winsor,I.Dubrovska,O.Kiryukhina,F.Bagnoli,F.Falugi,M.Bottomley,G.Grandi,W.F.Anderson,Center For Structural Genomics Of Infectious Diseases (Csgid) 
Responsible person
Ekaterina Filippova 
Responsible lab
Northwestern University 
Deposition Date
Mar 14, 2011 
Release Date
Mar 23, 2011 

Annotation

Description
The staphylococcal superantigen-like proteins (SSLs) are a family of polymorphic paralogs encoded in the Staphylococcus aureus genome whose function is unknown. Here, we report crystal structure of SACOL0473 determined at 2.3 A resolution. The crystal structure of SACOL0473 was compared to other SSLs and that of a classical superantigen, streptococcal pyrogenic exotoxin. The ability of these secreted proteins to target antigen-presenting cells may enhance a misplaced antibody response against the proteins, which may facilitate bacterial colonization. Like classical superantigens, therefore, SACOL0473 may distract the host's immune system, but it may do so via entirely different molecular mechanism.  
Functional assignment
 

Ligands

Ligand code Name Ligand type

Structure information

Unit cell parameters

Space Group
P 43 21 2  
Unit Cell

a=62.61Å, b=62.61Å, c=129.07Å
α=90.00, β=90.00, γ=90.00 
Solvent content
 
Matthews coefficient
 

Refinement

Data for the highest resolution shell is in parentheses.
Resolution range
45.00-2.30Å (2.36-2.30Å)  
Rall(%)
19.2 
Rwork(%)
18.9 (22.3) 
Rfree(%)
25.5 (39.1) 
Num. observed reflections
11928 (830) 
Num. Rfree reflections
572 (50) 
Completeness(%)
99.1 (96.1) 

Model parameters

Num Atoms
1585  
Num Waters
118  
Num Hetatoms
119  
Model mean isotropic B factor
26.950Å2  
RMSD bond length
0.016Å  
RMSD bond angle
1.918°  
Filename uploaded
rcsb064406.pdb (uploaded on Mar 24, 2011 12:06 PM)  
Inserted
Mar 24, 2011