Annotation

Description

The mouse monoclonal antibody, ZV-2, is specific for Zika virus. It does not cross-react to West Nile virus, Japanese encephalitis virus, or Dengue virus types -1, -2, -3, or -4. It recognizes a unique patch in domain III (DIII) of the Zika envelope protein that falls within the beta-sheet comprised of the ABDE strands. ZV-2 is an IgG2c isotype antibody that poorly neutralizes common African, American, and Asian Zika virus strains.  

Functional assignment

vaccine 

Structure information

Unit cell parameters

Space Group

P 21 21 21  

Unit Cell

a=39.02Å, b=113.44Å, c=132.97Å
α=90.00, β=90.00, γ=90.00 

Solvent content

 

Matthews coefficient

 

Refinement

Data for the highest resolution shell is in parentheses.

Resolution range

37.44-1.65Å (1.71-1.65Å)  

R_all(%)

19.2 

R_work(%)

19.0 (0.0) 

R_free(%)

22.1 (29.2) 

Num. observed reflections

71267 (7038) 

Num. R_free reflections

3556 (282) 

Completeness(%)

98.8 (99.0) 

Model parameters

Num Atoms

4253  

Num Waters

690  

Num Hetatoms

18  

Model mean isotropic B factor

31.690Ų  

RMSD bond length

0.004Å  

RMSD bond angle

0.752°  

RMSD dihedral angle

12.96°

 

Filename uploaded

pdb_extract_coord_29678.cif (uploaded on Nov 23, 2016 3:15 PM)  

Inserted

Nov 23, 2016