Structure of IDP95734

Zika specific antibody, ZV-48, bound to ZIKA envelope DIII

Edit deposit information
CSGID target
IDP95734 
PDB Id
5KVE (NCBI MMDB
Authors
H.Zhao,C.A.Nelson,D.H.Fremont,Center For Structural Genomics Of Infectious Diseases (Csgid) 
Responsible person
Chris Nelson 
Responsible lab
Washington University 
Deposition Date
Jul 14, 2016 
Release Date
Aug 10, 2016 

Annotation

Description
The mouse monoclonal antibody, ZV-48, is specific for Zika virus. It does not cross-react to West Nile virus, Japanese encephalitis virus, or Dengue virus types -1, -2, -3, or -4. ZV-48 strongly neutralizes the French Polynesian 2013 strain of Zika virus now circulating in the Americas. It recognizes the C-C'' loop on domain III (DIII) of the Zika envelope protein. 
Functional assignment
vaccine 

Ligands

Ligand code Name Ligand type
NA Sodium ion crystallization
SO4 crystallization
ACT acetate crystallization
EDO crystallization

Structure information

Unit cell parameters

Space Group
C 2 2 21  
Unit Cell

a=63.24Å, b=87.98Å, c=147.52Å
α=90.00, β=90.00, γ=90.00 
Solvent content
 
Matthews coefficient
 

Refinement

Data for the highest resolution shell is in parentheses.
Resolution range
48.50-1.70Å (1.76-1.70Å)  
Rall(%)
18.8 
Rwork(%)
18.7 (0.0) 
Rfree(%)
21.3 (33.6) 
Num. observed reflections
44558 (4335) 
Num. Rfree reflections
2294 (289) 
Completeness(%)
97.7 (96.0) 

Model parameters

Num Atoms
2554  
Num Waters
619  
Num Hetatoms
39  
Model mean isotropic B factor
29.480Å2  
RMSD bond length
0.003Å  
RMSD bond angle
0.667°  
RMSD dihedral angle
11.739°
 
Filename uploaded
5kve.pdb (uploaded on Nov 23, 2016 4:06 PM)  
Inserted
Nov 23, 2016