Structure of IDP95734

Zika specific antibody, ZV-67, bound to ZIKA envelope DIII

Edit deposit information
CSGID target
IDP95734 
PDB Id
5KVG (NCBI MMDB
Authors
H.Zhao,C.A.Nelson,D.H.Fremont,Center For Structural Genomics Of Infectious Diseases (Csgid) 
Responsible person
Chris Nelson 
Responsible lab
Washington University 
Deposition Date
Jul 14, 2016 
Release Date
Aug 03, 2016 

Annotation

Description
The mouse monoclonal antibody, ZV-67, is specific for Zika virus. It does not cross-react to West Nile virus, Japanese encephalitis virus, or Dengue virus types -1, -2, -3, or -4. ZV-67 strongly neutralizes a wide range of Zika virus, including strains from Africa, Asia, and the Americas. It recognizes the "lateral ridge" region on domain III (DIII) of the Zika envelope protein.  
Functional assignment
vaccine 

Ligands

Ligand code Name Ligand type
PCA pyroglutamic acid modified residue
CL CHLORIDE ION crystallization

Structure information

Unit cell parameters

Space Group
P 21 21 21  
Unit Cell

a=73.11Å, b=82.93Å, c=93.26Å
α=90.00, β=90.00, γ=90.00 
Solvent content
 
Matthews coefficient
 

Refinement

Data for the highest resolution shell is in parentheses.
Resolution range
61.97-1.40Å (1.45-1.40Å)  
Rall(%)
15.0 
Rwork(%)
14.8 (0.0) 
Rfree(%)
17.9 (25.2) 
Num. observed reflections
117559 (11045) 
Num. Rfree reflections
5889 (559) 
Completeness(%)
100.0 (100.0) 

Model parameters

Num Atoms
4109  
Num Waters
1010  
Num Hetatoms
2  
Model mean isotropic B factor
20.940Å2  
RMSD bond length
0.006Å  
RMSD bond angle
0.940°  
RMSD dihedral angle
16.32°
 
Filename uploaded
5kvg.pdb (uploaded on Nov 23, 2016 5:05 PM)  
Inserted
Nov 23, 2016