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Structure of IDP90271

Crystal Structure of Swine Flu Virus NS1 Effector Domain fromH1N1 Influenza A/California/07/2009.

Edit deposit information
CSGID target
IDP90271 
PDB Id
3M5R (NCBI MMDB
Authors
D.H.Fremont,Y.Y.L.Yu,C.A.Nelson,Center For Structural Genomics Of Infectious Diseases (Csgid) 
Responsible person
Chris Nelson 
Responsible lab
Washington University 
Deposition Date
Mar 13, 2010 
Release Date
Apr 07, 2010 

Annotation

Description
The nonstructural protein NS1 is employed by influenza virus to evade host immune responses. Several studies have implicated the NS1 protein in conferring increased pathogenicity and virulence on emergent influenza strains. The NS1 virulence factor is believed to participate in multiple host-cell interactions regulating processes as diverse as viral replication, host innate and adaptive immunity, and cellular signaling. The NS1 protein consists of a N-terminal RNA-binding domain and a C-terminal protein-binding "effector" domain. The protein is being studied both for its potential in vaccine development and for its potential in antiviral drug design. 
Functional assignment
 

Ligands

Ligand code Name Ligand type

Structure information

Unit cell parameters

Space Group
P 1 21 1  
Unit Cell

a=73.53Å, b=70.80Å, c=96.69Å
α=90.00, β=110.30, γ=90.00 
Solvent content
52.98  
Matthews coefficient
2.62  

Refinement

Data for the highest resolution shell is in parentheses.
Resolution range
50.00-2.01Å (2.08-2.01Å)  
Rall(%)
20.8 
Rwork(%)
20.7 (25.6) 
Rfree(%)
24.4 (31.2) 
Num. observed reflections
57329 (4659) 
Num. Rfree reflections
1547 (127) 
Completeness(%)
91.8 (0.8) 

Model parameters

Num Atoms
5848  
Num Waters
288  
Num Hetatoms
288  
Model mean isotropic B factor
40.530Å2  
RMSD bond length
0.008Å  
RMSD bond angle
1.104°  
RMSD dihedral angle
14.7°
 
Filename uploaded
pdb_extract_coord_13282.cif (uploaded on Mar 16, 2010 4:15 PM)  
Inserted
Mar 16, 2010