Center for Structural Genomics of Infectious Diseases

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Structure of IDP90748

CSGID target: IDP90748
PDB Id: 3R0S (NCBI MMDB)
Authors: 'J.Osipiuk,M.Zhou,L.Papazisi,W.F.Anderson,A.Joachimiak,Center For Structural Genomics Of Infectious Diseases (Csgid)'
Responsible person: Jerzy Osipiuk
Responsible lab: Argonne National Laboratory
Deposition Date: Mar 08, 2011
Release Date: Mar 23, 2011

Description: UDP-GlcNAc acyltransferase (LpxA) catalyzes the first step of lipid A biosynthesis, the transfer of R-3-hydroxymyristic acid from acyl carrier protein to the 3′-hydroxyl group of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc). Lipid A, a phosphorylated glucosamine disaccharide carrying long-chain saturated fatty acids, is the hydrophobic anchor of lipopolysaccharide (LPS) to the outer monolayer of Gram-negative bacteria. Lipid A is a very potent stimulant of the human immune system. When present in the body at high concentrations during a Gram-negative bacterial infection, may cause shock and death by an "out of control" excessive immune reaction. Lipid A biosynthetic enzymes have no mammalian counterparts. Thus, they are attractive targets for the design of new antibiotics.
Functional assignment: Transferase

Ligand code	Name	Ligand type
MSE		modified residue
175	3,5-dihydro-5-methylidene-4h-imidazol-4-on