The shikimate pathway links metabolism of carbohydrates to biosynthesis of aromatic compounds. In a sequence of seven steps, phosphoenolpyruvate and erythrose 4-phosphate are converted to chorismate, a precursor of the aromatic amino acids and many secondary aromatic metabolites. The shikimate pathway is essential for most bacteria and plants but absent in humans, making it an attractive target for the development of novel antibiotics. Chorismate synthase is the final enzyme in the shikimate pathway and catalyzes the conversion of 5-enolpyruvyl-3-shikimate phosphate to chorismate. The enzyme forms a 4-layer sandwich. Nearly a quarter of the residues in the protein, many of which form a portion of the active site, are disordered.