Aminoglycosides comprise a large, structurally diverse family of water-soluble polycationic antibiotics, such as gentamicin and kanamycin (Azucena and Mobashery, 2001).
mechanisms. Aminoglycoside N-acetyltransferases (AACs) serve as one component of the bacterical antibiotic resistance mechanisms against aminoglycosides. By acetylating amino groups in an acetyl-CoA-dependent manner, these enzymes are capable of abolishing the activity of these antibiotics (Llano-Sotelo, 2002).
This structure is that of the apo-form of the putative aminoglycoside N-acetyltransferase BA2930 from Bacillus anthracis. Analysis of the structure indicates that it possesses a characteristic fold identified for only one other N-acetyltransferase, that of the Antibiotic_NAT family from Bacillus subtilis (PDB code 2NYG). Analysis of the binding mode of the ligands for the enzyme may significantly contribute to existing knowledge of the mechanisms of anthrax drug resistance.