Oxidoreductases are implicated in a number of pathways and no specific role has been yet associated to STM2406 from S. typhimurium, although it has been determined to be an essential gene of this organism. It shares 58% sequence identity to YghZ, an alpha-aldo-ketoreductase for the toxic metabolic bi-product methylglyoxyl (FEMS Microbiol Lett. 2003 Jan 21;218(1):93-9). In addition YghZ could also be a more promiscuous aldo-ketoreductase; a recent paper has pointed to the possibility that YghZ could catalyze the stereospecific, NADPH-dependent reduction of l-glyceraldehyde 3-phosphate and thus provide another route to synthesis of dihydroxyacetone phosphate as a way to bipass Triose phosphate isomerase (Biochemistry. 2008 Aug 5; 47(31):7983-5). The fold is characteristic of this group of enzymes and comprises a parallel beta/alpha-barrel. A catalytic quartet of residues was found: Tyr-66, His-138, Lys-97 and Asp-61.