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Structure of IDP90222

Crystal Structure of YqeH GTPase from Bacillus anthracis with dGDP Bound

Edit deposit information
CSGID target
IDP90222 
PDB Id
3H2Y (NCBI MMDB
Authors
J.S.Brunzelle,S.M.Anderson,X.Xu,A.Savchenko,W.F.Anderson,Center For Structural Genomics Of Infectious Diseases (Csgid) 
Responsible person
Joseph Brunzelle 
Responsible lab
Northwestern University 
Deposition Date
Apr 15, 2009 
Release Date
Jun 16, 2009 

Annotation

Description
YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically present in bacteria with probable acquisition by plants from chloroplasts. Proteins of the YqeH family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. 
Functional assignment
GTP Binding 

Ligands

Ligand code Name Ligand type
GDP
MSE SELENOMETHIONINE modified residue

Structure information

Unit cell parameters

Space Group
C 1 2 1  
Unit Cell

a=83.13Å, b=58.99Å, c=77.72Å
α=90.00, β=99.38, γ=90.00 
Solvent content
45.52  
Matthews coefficient
2.26  

Refinement

Data for the highest resolution shell is in parentheses.
Resolution range
76.70-1.80Å (1.85-1.80Å)  
Rall(%)
20.9 
Rwork(%)
20.8 (25.2) 
Rfree(%)
23.7 (28.1) 
Num. observed reflections
34007 (2494) 
Num. Rfree reflections
1700 (121) 
Completeness(%)
98.4 (97.8) 

Model parameters

Num Atoms
2586  
Num Waters
126  
Num Hetatoms
0  
Model mean isotropic B factor
52.980Å2  
RMSD bond length
0.016Å  
RMSD bond angle
1.390°  
Filename uploaded
idp90222.pdb (uploaded on Apr 15, 2009 7:55 AM)  
Inserted
Apr 15, 2009