Center for Structural Genomics of Infectious Diseases

To see full content of that page you need the activeISee plugin.
Get the latest version from here.

Structure of IDP02355

CSGID target: IDP02355
PDB Id: 3JTJ (NCBI MMDB)
Authors: J.Osipiuk,M.Zhou,S.Grimshaw,W.F.Anderson,A.Joachimiak,Center For Structural Genomics Of Infectious Diseases (Csgid)
Responsible person: Jerzy Osipiuk
Responsible lab: Argonne National Laboratory
Deposition Date: Sep 12, 2009
Release Date: Sep 22, 2009

Description: The enzyme 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase; CKS) catalyzes the activation of 3-deoxy-D-manno-octulosonate (or 2-keto-3-deoxy-manno-octonic acid; KDO) by forming CMP-KDO. The enzymes belong to cytidylyltransferase protein family being a part of GT-A clan that contains diverse glycosyltransferases that possess a Rossmann like fold. KDO is an essential component of lipopolysaccharides (LPS) in Gram-negative bacteria. Incorporation of KDO into LPS requires its activation by 3-deoxy-manno-octulosonate CKS. The Yesinia pestis enzyme coded by kdsB gene is 77% identical to its E.coli homolog. Two isozymes of CKS have been found in Escherichia coli. One of them, named L-CKS, is encoded by the kdsB gene and participates in the biosynthesis of LPS. The other isozyme, K-CKS, is encoded by the kpsU gene and is involved in capsule expression. CKS is unique to Gram-negative bacteria and is absent from mammalian cells. Therefore, CKS is an attractive target for the development of antibacterial agents.
Functional assignment

Ligand code	Name	Ligand type
IMD
MSE		modified residue