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Structure of IDP02545

Crystal Structure of Beta-Lactamase from Francisella tularensis

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CSGID target
IDP02545 
PDB Id
3P09 (NCBI MMDB) 
Authors
Y.Kim,M.Makowska-Grzyska,J.Hasseman,W.F.Anderson,A.Joachimiak,Center For Structural Genomics Of Infectious Diseases (Csgid) 
Responsible person
Youngchang Kim 
Responsible lab
Argonne National Laboratory 
Deposition Date
Sep 27, 2010 
Release Date
Oct 13, 2010 

Annotation

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Description
Beta-lactamases, produced by some bacteria, are responsible for the resistance to the bata-lactam antibiotics such as penicillins, cephamycins, and carbapennems. The beta-latamse from Francisella tularensis is a class A lactamase with all catalytic residues (SXXK, SXN, KTG) in the three regions involved in catalysis are conserved in the same location of the binding site.  
Functional assignment
 

Ligands

Ligand code Name Ligand type
GOL glycerol
SO4 sulfate
MSE modified residue

Structure information

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Unit cell parameters

Space Group
P 21 21 2  
Unit Cell

a=77.65Å, b=143.47Å, c=46.89Å
α=90.00, β=90.00, γ=90.00 
Solvent content
38.91  
Matthews coefficient
2.01  

Refinement

Data for the highest resolution shell is in parentheses.
Resolution range
40.72-1.90Å (1.97-1.90Å)  
Rall(%)
16.4 
Rwork(%)
16.2 (23.9) 
Rfree(%)
20.7 (28.3) 
Num. observed reflections
42513 (3184) 
Num. Rfree reflections
2100 (157) 
Completeness(%)
95.7 (76.0) 

Model parameters

Num Atoms
4207  
Num Waters
377  
Num Hetatoms
418  
Model mean isotropic B factor
33.370Å2  
RMSD bond length
0.007Å  
RMSD bond angle
1.024°  
RMSD dihedral angle
12.67°
 
Filename uploaded
dep.pdb (uploaded on Oct 05, 2010 6:45 AM)  
Inserted
Oct 05, 2010