Center for Structural Genomics of Infectious Diseases

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Structure of IDP01139

CSGID target: IDP01139
PDB Id: 3Q6D (NCBI MMDB)
Authors: 'J.Osipiuk,M.Makowska-Grzyska,L.Papazisi,W.F.Anderson,A.Joachimiak,Center For Structural Genomics Of Infectious Diseases (Csgid)'
Responsible person: Jerzy Osipiuk
Responsible lab: Argonne National Laboratory
Deposition Date: Dec 31, 2010
Release Date: Feb 02, 2011

Description: Xaa-Pro dipeptidase, also known as prolidase, hydrolizes dipeptides having proline as the second residue. Enzymes of this type have been found in mammals, bacteria, and archeon Pyrococcus horikoshii. In humans, prolidase is involved in the final stage of the degradation of endogenous and dietary proteins, and is particularly important in collagen catabolism. Mutations in the gene encoding for human prolidase cause an autosomal recessive disorder characterized by skin lesions, mental retardation, and recurrent infections. The physiological role of the enzyme in bacteria is not established. In general, proline-specific peptidases participate with other peptidases in the terminal degradation of intracellular proteins, and may function in the recycling of proline.
Functional assignment: Peptidase

Ligand code	Name	Ligand type
GOL	glycerol	crystallization
175	3,5-dihydro-5-methylidene-4h-imidazol-4-on