E.V.Filippova,A.Halavaty,L.Shuvalova,G.Minasov,I.Dubrovska,J.Winsor,O.Kiryukhina,L.Papazisi,F.Bagnoli,F.Falugi,M.Bottomley,G.Grandi,W.F.Anderson,Center For Structural Genomics Of Infectious Diseases (Csgid)
Here, we report the crystal structure of a hypothetical protein from Staphylococcus aureus subsp. aureus NCTC 8325. Preliminary bioinformatic analysis suggests that protein belongs to lipoproteins. 54 N-terminal and 43 C-terminal residues are missing in the structure. These N- and C-terminal regions are very polar and have a lot of charged residues and are probably disordered and very accessible to proteases. The asymmetric unit cell contains two protein subunits. Combined with the crystal symmetry these two subunits form a fourfold helix that could be important for a biological function.