The target protein idp00649 was assign as a protein with unknown function. It consists of two domains: N-terminal Domain, which is similar to metallo-beta-lactamase family proteins (PF00753) and C-terminal Rhodanese-like Domain (PF00581). Metallo-beta-lactamases are important enzymes, which are involved in the breakdown of antibiotics by antibiotic-resistant bacteria. Usually these proteins bind two zinc ions per molecule as cofactor. The superposition of N-terminal domain of idp00649 with the metallo-beta-lactamase from Bacillus cereus (PDB code 1BMC) shows close match in the fold for these proteins, and the match in the position of metals bound to the active site. But these two proteins have very low sequence homology. C-terminal domain, which has Rhodanese-like fold, also shows very low sequence homology to the proteins of this family. Furthermore, very important Cysteine in the active site of Rhodanese, which is involved in detoxification of cyanide, is missing in the C-terminal Domain of idp00649. So, function and specificity of these domain and protein as whole still remains unknown.