Structure of IDP95734

Zika specific antibody, ZV-64, bound to ZIKA envelope DIII

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CSGID target
IDP95734 
PDB Id
5KVF (NCBI MMDB) 
Authors
H.Zhao,C.A.Nelson,D.H.Fremont,Center For Structural Genomics Of Infectious Diseases (Csgid) 
Responsible person
Chris Nelson 
Responsible lab
Washington University 
Deposition Date
Jul 14, 2016 
Release Date
Aug 03, 2016 

Annotation

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Description
The mouse monoclonal antibody, ZV-64, is specific for Zika virus. It does not cross-react to West Nile virus, Japanese encephalitis virus, or Dengue virus types -1, -2, -3, or -4. ZV-64 strongly neutralizes the French Polynesian 2013 strain of Zika virus now circulating in the Americas. It recognizes the C-C'''' loop on domain III (DIII) of the Zika envelope protein.  
Functional assignment
vaccine 

Ligands

Ligand code Name Ligand type
PCA modified residue
GOL glycerol crystallization

Structure information

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Unit cell parameters

Space Group
P 21 21 21  
Unit Cell

a=59.68Å, b=92.16Å, c=96.25Å
α=90.00, β=90.00, γ=90.00 
Solvent content
 
Matthews coefficient
 

Refinement

Data for the highest resolution shell is in parentheses.
Resolution range
19.74-1.40Å (1.44-1.40Å)  
Rall(%)
15.5 
Rwork(%)
15.4 (0.0) 
Rfree(%)
18.7 (30.4) 
Num. observed reflections
110240 (10362) 
Num. Rfree reflections
5600 (367) 
Completeness(%)
100.0 (100.0) 

Model parameters

Num Atoms
4205  
Num Waters
676  
Num Hetatoms
30  
Model mean isotropic B factor
21.460Å2  
RMSD bond length
0.005Å  
RMSD bond angle
0.850°  
RMSD dihedral angle
17.96°
 
Filename uploaded
5kvf.pdb (uploaded on Nov 23, 2016 4:43 PM)  
Inserted
Nov 23, 2016