Structure of IDP90205

Crystal structure of Cowpox virus CPXV018 (OMCP) bound to human NKG2D

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CSGID target
IDP90205 
PDB Id
4PDC (NCBI MMDB) 
Authors
'E.Lazear,C.A.Nelson,D.H.Fremont,Center For Structural Genomics Of Infectious Diseases (Csgid)' 
Responsible person
Chris Nelson 
Responsible lab
Washington University 
Deposition Date
Apr 17, 2014 
Release Date
May 21, 2014 

Annotation

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Description
The Natural Killer Cell receptor NKG2D is a key component of the human innate immune system. The NKG2D receptor allows Natural Killer Cells to recognize tumors and viral-infected cells. Cowpox and monkeypox viruses evade immune detection by producing OMCP, a high affinity secreted antagonist of NKG2D.  
Functional assignment
immune evasion 

Ligands

Ligand code Name Ligand type

Structure information

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Unit cell parameters

Space Group
P 1 21 1  
Unit Cell

a=43.31Å, b=101.11Å, c=91.37Å
α=90.00, β=91.63, γ=90.00 
Solvent content
 
Matthews coefficient
 

Refinement

Data for the highest resolution shell is in parentheses.
Resolution range
45.67-1.99Å (0.00-0.00Å)  
Rall(%)
16.8 
Rwork(%)
16.6 (0.0) 
Rfree(%)
21.4 (0.0) 
Num. observed reflections
52036 (0) 
Num. Rfree reflections
2071 (0) 
Completeness(%)
92.9 (0.0) 

Model parameters

Num Atoms
12595  
Num Waters
660  
Num Hetatoms
660  
Model mean isotropic B factor
29.800Å2  
RMSD bond length
0.003Å  
RMSD bond angle
0.786°  
RMSD dihedral angle
13.423°
 
Filename uploaded
4pdc.pdb (uploaded on Nov 28, 2016 4:45 PM)  
Inserted
Nov 28, 2016