Annotation

Description

Human norovirus is thought to be the most common cause of acute gastroenteritis worldwide, which has earned it the common names of cruise ship virus or winter vomiting bug. Murine norovirus (MNoV) is a closely related virus that is widely accepted as the primary animal model for human norovirus infection.  The mechanisms of norovirus capsid interactions with host receptors and the mechanisms by which soluble cofactors augment these interactions to promote infection are not well understood. This entry contains a fragment of the MNoV capsid -- the dimeric MNoV VP1 protruding (P) domain -- in complex with the murine CD300lf receptor. 

Functional assignment

VIRULENCE 

Structure information

Unit cell parameters

Space Group

P 21 21 21  

Unit Cell

a=48.71Å, b=135.25Å, c=139.52Å
α=90.00, β=90.00, γ=90.00 

Solvent content

 

Matthews coefficient

 

Refinement

Data for the highest resolution shell is in parentheses.

Resolution range

62.00-0.00Å (2.07-2.00Å)  

R_all(%)

18.3 

R_work(%)

18.2 (0.0) 

R_free(%)

22.5 (0.0) 

Num. observed reflections

57651 (3530) 

Num. R_free reflections

1902 (0) 

Completeness(%)

91.0 (57.0) 

Model parameters

Num Atoms

12734  

Num Waters

726  

Num Hetatoms

954  

Model mean isotropic B factor

33.460Ų  

RMSD bond length

0.004Å  

RMSD bond angle

0.600°  

RMSD dihedral angle

11.36°

 

Filename uploaded

P_CD300lf_deposit_20181702.pdb (uploaded on Mar 06, 2019 6:24 PM)  

Inserted

Mar 06, 2019