Annotation

Description

Murine norovirus (MNoV) is closely related to Human norovirus, the most common cause of acute gastroenteritis worldwide. The mechanisms by which soluble cofactors augment the interaction between the norovirus capsid protein and the host receptor are not well understood. This entry contains a fragment of the MNoV capsid, the dimeric MNoV VP1 protruding (P) domain, in complex with the murine CD300lf receptor, and in complex with the bile acid glycochenodeoxycholic acid.  

Functional assignment

VIRULENCE 

Structure information

Unit cell parameters

Space Group

P 21 21 21  

Unit Cell

a=49.10Å, b=134.82Å, c=139.59Å
α=90.00, β=90.00, γ=90.00 

Solvent content

 

Matthews coefficient

 

Refinement

Data for the highest resolution shell is in parentheses.

Resolution range

60.70-1.95Å (2.02-1.95Å)  

R_all(%)

21.1 

R_work(%)

20.8 (32.9) 

R_free(%)

25.7 (32.6) 

Num. observed reflections

62756 (1306) 

Num. R_free reflections

3244 (0) 

Completeness(%)

87.0 (19.3) 

Model parameters

Num Atoms

12645  

Num Waters

489  

Num Hetatoms

863  

Model mean isotropic B factor

38.200Ų  

RMSD bond length

0.007Å  

RMSD bond angle

0.612°  

RMSD dihedral angle

11.85°

 

Filename uploaded

GCDCA_ref3_36.pdb (uploaded on Mar 07, 2019 2:17 PM)  

Inserted

Mar 07, 2019