Structure of CPX_52010_52016

Crystal Structure of Nsp16-Nsp10 Heterodimer from SARS-CoV-2 with 7-methyl-GpppA and S-adenosyl-L-homocysteine in the Active Site and Sulfates in the mRNA Binding Groove.

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CSGID target
CPX_52010_52016 
PDB Id
6WRZ (NCBI MMDB) 
Authors
Minasov, G., Shuvalova, L., Rosas-Lemus, M., Brunzelle, J.S., Kiryukhina, O., Satchell, K.J.F., Center for Structural Genomics of Infectious Diseases (CSGID) 
Responsible person
George Minasov 
Responsible lab
Northwestern University 
Deposition Date
Apr 30, 2020 
Release Date
May 13, 2020 

Annotation

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Ligands

Ligand code Name Ligand type
SAH biological
GTA p1-7-methylguanosine-p3-adenosine-5',5'-triphosphate biological
MGP 7-methyl-guanosine-5'-triphosphate biological
SO4 sulfate crystallization
CL chloride crystallization
ZN zinc biological

Structure information

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Unit cell parameters

Space Group
P 31 2 1  
Unit Cell

a=169.15Å, b=169.15Å, c=51.83Å
α=90.00, β=90.00, γ=120.00 
Solvent content
 
Matthews coefficient
 

Refinement

Data for the highest resolution shell is in parentheses.
Resolution range
29.91-2.25Å (2.31-2.25Å)  
Rall(%)
16.3 
Rwork(%)
16.2 (21.2) 
Rfree(%)
19.0 (21.5) 
Num. observed reflections
40126 (2932) 
Num. Rfree reflections
1966 (133) 
Completeness(%)
99.0 (99.4) 

Model parameters

Num Atoms
3281  
Num Waters
220  
Num Hetatoms
393  
Model mean isotropic B factor
53.480Å2  
RMSD bond length
0.005Å  
RMSD bond angle
1.246°  
Filename uploaded
6wrz.pdb (uploaded on May 30, 2020 11:10 AM)  
Inserted
May 30, 2020